The human anti-mouse antibody (HAMA) reaction limits the therapeutic utility of mouse monoclonal antibodies. Humanization of mouse monoclonal antibodies by genetic engineering can improve the in ...

such as the human anti-mouse antibody (HAMA) response. This limits their clinical applications. To overcome this issue, genetic engineering can be used to humanize these antibodies, making them ...

The human immune system recognizes murine mAbs as foreign material, producing human anti-mouse antibodies (HAMAs ... and are less prone to HAMA reactions. If mAbs were to become a class of ...