The dark and smaller liver on the right is a typical healthy liver from a lean mouse. All the mice under the gray ... Foralumab, a fully human anti-CD3 monoclonal antibody, is a biological drug ...

Data were summarized with the search of 'colorectal' and 'antibody' as of August 2012 at ClinicalTrials.gov [202]. EGFR: EGF receptor; mAb: Monoclonal antibody; VEGFR: VEGF receptor. The authors ...

Researchers say study offers proof-of-concept that targeting how T cells interact with metabolites in their environment can ...

The presented data show that PHST001, through potent CD24 binding, promotes macrophage-induced phagocytosis in a number of cancer cells and significantly shrinks tumors in vivo. In addition, PHST001 ...

Department of Physiology, Harold Hamm Diabetes Center, The University of Oklahoma Health Science Center, Oklahoma City, United States ...

Tiziana Life Sciences, Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company developing breakthrough ...

Blocking a protein that imports lactic acid, a metabolic byproduct of cancer cells, reinvigorated exhausted T cells and led to improved tumor control in mouse models of cancer, according to a new ...

Here, we see antibodies from a human anti-NMDAR encephalitis patient (purple) binding to NMDARs (green) in a mouse brain. Areas marked red indicate high levels of antibody binding. Additionally ...

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic ...

Studying human tissue ... turned to mouse models of heart failure that have the very same type of fibroblasts. They used a therapeutic protein—called a monoclonal antibody—that blocks the ...