Feedback notes the flurry of new papers mentioning the mysterious "vegetative electron microscope", and ponders the emergence ...

Scientists found a compound that appears to counter common mutations behind POLG-related diseases, rare conditions that harm ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualize its structure at the atomic scale using ...

After 50 years of mystery, researchers at the University of Cambridge have revealed how a molecular machine inside ...

Electron microscopy (EM) allowed us to look at the mitochondria and EV on an ultrastructural level, which is not possible with fluorescence microscopy. Using EM, we were able to assess the vesicle’s ...

The graphic shows images of a cell under mtDNA replication stress made using so-called Correlative Light and Electron Microscopy (for short: CLEM). The mitochondrial DNA (mtDNA, green) is ejected ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to transport ...

Researchers at the University of Cologne found that mitochondrial dysfunction leads to early skeletal aging by disrupting cartilage metabolism. The study identified maladaptive metabolic shifts, ...

Mitochondrial diseases caused by POLG mutations vary in ... including by means of cryo-electron microscopy. “We demonstrate exactly where the molecule binds, between two separate chains of the enzyme.

Professor Kunji said, "Drugs inhibiting the function of the carrier can remodel how mitochondria work, which can be beneficial in certain conditions. Electron microscopy allows us to visualize ...

Mitochondrial diseases caused by POLG mutations ... including by means of cryo-electron microscopy. "We demonstrate exactly where the molecule binds, between two separate chains of the enzyme.