Rounding out the afternoon in the late window for Week 5 will be Tennessee at Arizona, Detroit in Cincinnati, taking on the Bengals, and Washington visiting the West Coast to face the Los Angeles Chargers. It's Week 5, and the NFL is down to its final two undefeated teams in the Eagles and Buffalo Bills.

Week 5 of the 2025-26 NFL regular season officially gets underway on Thursday, October 2, with a Thursday Night Football primetime clash featuring the NFC West rival San Francisco 49ers and Los Angeles Rams at SoFi Stadium.

The San Francisco 49ers versus the Los Angeles Rams is one of many strong options on the Week 5 NFL slate. With Week 5 in the NFL upon us, stay on top of the latest betting odds with our preview below.

The Baltimore Ravens are limping into a Week 5 matchup with the visiting Houston Texans, missing five All-Pro players. Quarterback Lamar Jackson, linebacker Roquan Smith, and safety Kyle Hamilton are all out for Sunday's game with hamstring injuries.

Week 5 of the NFL season marked the first time in 2025 that not all 32 teams were in action, as the Chicago Bears, Green Bay Packers, Atlanta Falcons, and Pittsburgh Steelers enjoyed the season's first byes. This week, two more teams will sit out.

After analyzing the Commanders vs. Chiefs props and examining the dozens of NFL player prop markets, the SportsLine's Machine Learning AI says Marcus Mariota goes Under 199.5 passing yards for Washington (-113).