The No. 23 USC Trojans are set to face off against the Nebraska Cornhuskers on Saturday night at Memorial Stadium in Lincoln. The matchup between the Trojans an

College football Week 8 odds, picks, predictions, TV channel, streaming for USC Trojans vs Notre Dame Fighting Irish game on Saturday, Oct. 18, 2025.

With the Trojans and Irish set to meet for the 96th time, the future of the rivalry is uncertain. The Southern California Roundtable is worried

The No. 23 USC Trojans are currently a potential contender for the College Football Playoff sitting at 5-2 overall. USC also stands with four other Big Ten teams fighting for a playoff spot, making the Trojans' path an uphill climb.

The model is also backing USC (-4.5) to cover the spread on the road against Nebraska, while the Under (55.5) hits 66% of the time in Cincinnati vs. Utah. Before locking in your Week 10 college football picks, be sure to check out the top college football betting picks from SportsLine's advanced computer model.

USC is off in Week 6 of the college football season, as it receives an extra week to prepare for its upcoming game against Michigan. It's USC's first off week of the season, as it has another off week on Oct. 25, ahead of its road contest against Nebraska on Nov. 1.

The US LBM Coaches Poll No. 15 Notre Dame Fighting Irish (4-2) host the No. 21 USC Trojans (5-1) in South Bend, Indiana, on Saturday (Oct. 18). The contest will be huge for both teams because both are fighting for a spot in the College Football Playoff.

USC is getting strong play from QB Jayden Maiava, but the Trojans must improve on defense in the final month of the season.