In the present study, we identify Pten, from among several candidates, as a crucial mediator of BCR-coupled death through the inhibition of PIP3-dependent signaling in immature B cells ...

cell motility and survival. Activation of receptors by extracellular ligands activates PI3K, which causes the formation of PIP3 by phosphorylation. PIP3 then localizes AKT to the membrane ...