Purpose: A summary of the basic science underlying the current controversies regarding cyclooxygenase-2 (COX-2)-selective nonsteroidal antiinflammatory drugs (NSAIDs), including data on their ...

Celebrex (celecoxib) is a selective NSAID. It differs from non-selective NSAIDs because it targets the COX-2 enzyme, ...

1 Nonselective NSAIDs, which inhibit cyclo-oxygenase (COX)-1 and COX-2, and the newer COX-2-specific inhibitors are commonly used in the management of post-traumatic or post-operative skeletal pain.

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

NSAID research changed radically with the discovery that COX existed in two isoforms: the constitutively expressed COX-1 and an inducible COX-2 isoform 6. Analysis of the distribution of these ...

Meloxicam is also a selective COX-2 inhibitor, reducing the risk of GI side effects compared to naproxen. However, NSAIDs ...

Clinical trials of several COX-2 selective and nonselective NSAIDs of up to 3 years duration have shown an increased risk of serious cardiovascular thrombotic events, including myocardial ...

In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?

It is unclear if COX-2-selective NSAIDs also inhibit COX-3 and whether this inhibition could represent a primary central mechanism by which these drugs decrease pain and possibly fever.