Cohort and Sample ... mutant allele frequency; PC, prostate cancer; PDAC, pancreatic ductal adenocarcinoma; PTC, premature termination codons; SNV, single-nucleotide variations; Spl, splicing variants ...

FORE Biotherapeutics Presents New Plixorafenib Results at AACR 2025 Demonstrating Pharmacodynamic Effect in Clinical Tumor Biopsies and Decreased V600E Mutant Allele Frequency in ctDNA of 85% of ...

The effective sample sizes were between 151,188 ... Quality control included filtering SNPs based on allele types, minor allele frequency, and imputation quality. Exploratory and confirmatory ...

accurately detects BRAF mutations in tumor biopsies and change in variant allele frequency (VAF) of BRAF mutation in ctDNA may be a surrogate marker for monitoring disease. The data is being ...