Muscle contraction involves the cyclic interaction of the myosin cross-bridges with the actin filament, which is coupled to steps in the hydrolysis of ATP 1. While bound to actin each cross-bridge ...

Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver its payload of cell ...

The hydrolysis of ATP provides the required energy for active ... This breaks the cross-bridge between myosin and actin filaments, thereby releasing myosin for the next contraction.

Biomolecular condensates are distinct molecular communities made of DNA, RNA and proteins that "condense" molecules to key ...

As myosin moves along the actin filaments, it converts chemical energy (through the hydrolysis of ATP) into mechanical force. This drives the shortening of structures within the muscle fiber ...

"I think this work provides a fundamental molecular understanding of how actin filaments catalyze ATP hydrolysis, which in turn is critical to their behavior," Voth told Phys.org. "ATP hydrolysis ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...

Immune cells, for example, use actin filaments to move and hunt bacteria and viruses. Researchers knew already that the filaments’ dynamics is regulated by ATP hydrolysis – the reaction of ATP with ...

In ATP hydrolysis, water is used to split apart adenosine triphosphate (ATP) to create adenosine diphosphate (ADP) to get energy. ATP hydrolysis energy (AHE) is then used in the activities of ...

Arg674 is highly conserved evolutionarily, localizes to the actin-binding domain of the perinatal myosin head, and is close to the ATP-binding site. We identified nonsynonymous MYH8 polymorphisms ...