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Novak Djokovic was beaten 7-6 (6), 6-3 by big-serving Reilly Opelka in the Brisbane International quarterfinals on Friday. Opelka served 16 aces — including one to finish off each set — to earn one of the biggest wins of the American's career.

Djokovic is in search of his 25th Grand Slam title at the Australian Open, but fell short of the semifinals at his warm-up event.

Novak Djokovic will not play any further part in this year's Brisbane International as Reilly Opelka has sealed the biggest win yet of his return to the sport after having most of the last 18 months on the sidelines injured.

Reilly Opelka secured the biggest win of his comeback over Novak Djokovic in the Brisbane International quarterfinals.

Novak Djokovic's hunt for a landmark 100th ATP title ended with a whimper following an unexpected 7-6(6) 6-3 defeat by big-serving American Reilly Opelka in the Brisbane International quarter-finals on Friday.

Former world number one Novak Djokovic's Australian Open preparations suffered a blow Friday as he was bundled out of the Brisbane International by towering American Reilly Opelka.The Australian Open starts on January 12.