Seguin is a city in and the county seat of Guadalupe County, Texas, United States. The population was 29,433 at the 2020 census, and a…Seguin is a city in and the county seat of Guadalupe County, Texas, United States. The population was 29,433 at the 2020 census, and according to 2023 census estimates, the city is estimated to have a population of 36,013.
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