CCR6–CCL20 Axis in IBD: What Have We Learnt in the Last 20 …
WEBAug 21, 2018 · A microarray gene expression patterns of active IBD patient colons presented CCL20 as an important molecule indicating the potential role in IBD pathogenesis. CCL20 as well as CXCL 1–3 and 8 along with the receptors, CCR6, CXCR1 and 2 were found to be distinctive in the acute phase of colonic IBD.
Expression of CCL20 and Its Corresponding Receptor CCR6 Is …
WEBNov 4, 2015 · Background: The chemokine CCL20 and its receptor CCR6 are putative drug targets in inflammatory bowel disease, and CCL20 is a novel IBD predilection gene. Previous findings on the CCL20 response in these diseases are divergent.
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
WEBJul 1, 2021 · This review discussed the importance of the CCR6-CCL20 axis in IBD, PS, RA, and MS, and recent advances in targeting the CCR6-CCL20 in controlling these autoimmune diseases.
Discovery of small-molecules targeting the CCL20/CCR6 axis as …
WEBDec 5, 2022 · We decided to combine in silico target-based drug design (CCR6 antagonist) and in vitro functional assays (blockage of CCL20-induced chemotaxis) to identify new small molecules acting on the CCL20/CCR6 axis and …
WEBThis Review sum-marizes the critical mediators and mechanisms involved in immune cell trafficking in IBD and the available evidence for efficacy, safety and pharmacokinetics of S1P receptor...
CCR6-CCL20 axis as a therapeutic target for autoimmune diseases
WEBJul 1, 2021 · In the current review, we discussed the role of the CCR6-CCL20 axis in pathogenesis and its potential use as a therapeutic target in PS, IBD, RA, and MS in detail. We also listed important molecules that can target or inhibit the CCR6-CCL20 axis to control several autoimmune diseases (Table 1).
C-C Motif Ligand 20 (CCL20) and C-C Motif Chemokine Receptor …
WEBOct 20, 2018 · The chemokine C-C motif ligand 20 (CCL20) is increased in the colonic mucosa during active inflammatory bowel disease (IBD) and can be found both in the epithelium and immune cells in the lamina propria.
Gastrointestinal Disorders | Free Full-Text | CCR6–CCL20-Mediated ...
WEBJul 17, 2018 · Among a plethora of functions, chemotactic navigation of effector T helper cell cohorts to the gut mucosa from lymphatics appears to be primarily a CCR6-driven mechanism, which synchronizes immune homeostasis during IBD pathophysiology. The CCR6–CCL20 axis is a prominent immune modulator in both innate and adaptive immune responses of a wide ...
Strategies for targeting cytokines in inflammatory bowel disease
WEBMar 14, 2024 · Cytokines produced by immune cells contribute to the development and perpetuation of inflammatory bowel disease (IBD), namely Crohn’s disease and ulcerative colitis, by regulating various aspects...
Modulation of the CCR6-CCL20 Axis: A Potential Therapeutic …
WEBNov 16, 2018 · A plethora of research studies have demonstrated that the CCR6 and CCL20 axis directly influences the nervous, respiratory, gastrointestinal, excretory, skeletal, and reproductive systems via pleiotropic immune mechanisms, manifesting as diseases with high mortality rates.